meropenem side effects in cats

From: Side Effects of Drugs Annual, 2011. J01DH02 - meropenem ; Belongs to the class of carbapenems. NLM Hamacher J, Vogel F, Lichey J, Kohl FV, Diwok K, Wendel H, Lode H "Treatment of acute bacterial exacerbations of chronic obstructive pulmonary disease in hospitalised patients--a comparison of meropenem and imipenem/cilastatin. J Antimicrob Chemother. Meropenem. Infection 24 (1996): 473-9, 11. Clin Pharmacokinet. Side effects of Merrem include nausea, vomiting, diarrhea, constipation, headache, or soreness, redness, or swelling at the injection site. Cats Label dose: 10-15mg/kg PO or IV q12h: For serious anaerobic infections: 25 – 50 mg/kg PO or IV q12h: For enteritis caused by Clostridium difficile: 62.5mg/cat PO q12h for 5d: For metronidazole benzoate: 25 mg/kg PO q12h : Dogs Label dose: 10-15mg/kg PO q12h: Brand Name(s) Flagyl® Background. Answered in 15 minutes by: 12/5/2010. Please enable it to take advantage of the complete set of features! Predictive Performance of Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling of Renally Cleared Drugs in Children. Free E-newsletter Subscribe to Housecall. PLoS Comput Biol. 2016. Applies to meropenem: intravenous powder for solution. 1985 Jul-Aug;7 Suppl 3:S447-51. Side effects not requiring immediate medical attention. 2. The safety of imipenem/cilastatin has not been established for animals that are pregnant or lactating. Meropenem. is supplied in 20 mL and 30 mL injection vials containing sufficient meropenem to deliver 500 mg or 1 g, respectively.  |  Rev Infect Dis. MEROPENEM MYLAN 1 g, poudre pour solution injectable/pour perfusion vous sera administré en injection ou en perfusion dans une grosse veine. Spectrum: Active against the following gram-positive organisms: Staphylococcus aureus, Streptococcus pneumoniae, Viridans group streptococci, Enterococcus faecalis. Infection 24 (1996): 480-4, 10. infections in cystic fibrosis patients." Wilson SE "Results of a randomized, multicenter trial of meropenem versus clindamycin/tobramycin for the treatment of intra-abdominal infections." The median age of dogs was 10 years (range, 1‐14), and the median age of cats was 13 years (range, 0‐19). In repeat dose studies of up to 6 months duration only minor effects were seen including a decrease in red cell parameters in dogs. Category: Veterinary. Meropenem. J Antimicrob Chemother 36(suppl a (1995): 145-56, 15. If you notice any behavioral or physiological side effects when administering this medication, contact your veterinarian immediately. You may report them to the FDA. 1995 Jul;50(1):73-101. doi: 10.2165/00003495-199550010-00007. Antimicrob Agents Chemother 42 (1998): 1233-8, 8. Carbapenem resistance is a growing problem in human medicine and is expecte… US Brand Name. Imipenem should not be used in animals with known hypersensitivity or allergy to the drug or other beta-lactams. In case of any doubt consult your doctor or pharmacist. General Description: Meropenem. USA.gov. Meropenem may also interact with some other medications. These side effects may go away during treatment as your body adjusts to the medicine. Amikacin can be stored at room temperature and is stable for up to 2 years. Description and Brand Names. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Zhanel GG, Wiebe R, Dilay L, et al. Drugs 68 (2008): 803-38, 5. Satisfied Customers: 7,210. Therapeutic Effects: Bactericidal action against susceptible bacteria. Side effects. Adequate and well-controlled studies of this drug in pregnant women are lacking, and this drug should be used during pregnancy only if clearly needed. Many Enterobacteriaceaethat are resistant to other antimicrobials will be susceptible to meropenem; therefore, use should be strictly reserved for infections caused by organisms that are resistant to other antimicrobial choices. Therefore, unlike imipenem, meropenem can be used without dehydropeptidase inhibitors to obtain a consistently high concentration in the urine without nephrotoxic effects. General Description: Meropenem. Meropenem, one of the newest of the carbapenem class of drugs has antibacterial activity approximately equal to, or greater than imipenem. Zeneca Pharmaceuticals, Wilmington, DE. [Ref], Common (1% to 10%): Pain, inflammation, sepsis/septicemia, shock, accidental injury, Uncommon (0.1% to 1%): Chest pain, fever, back pain, chills, pelvic pain, peripheral edema, abdominal enlargement[Ref], Common (1% to 10%): Inflammation at the injection site, phlebitis/thrombophlebitis, pain at the injection site, Uncommon (0.1% to 1%): Injection site reactions, edema at the injection site[Ref], Common (1% to 10%): Rash (including diaper/nappy area moniliasis), pruritus, Uncommon (0.1% to 1%): Urticaria, sweating, skin ulcer, Postmarketing reports: Toxic epidermal necrolysis, Stevens-Johnson syndrome, angioedema, erythema multiforme, severe skin reactions[Ref], Common (1% to 10%): Apnea, pharyngitis, pneumonia, Uncommon (0.1% to 1%): Respiratory disorder, dyspnea, pleural effusion, asthma, increased cough, hypoxia, lung edema, Frequency not reported: Respiratory failure[Ref], Heart failure occurred more often in patients with moderately severe renal dysfunction. Last updated on Jul 26, 2020. Serious side effects include Clostridium difficile infection, seizures, and allergic reactions including anaphylaxis. What are some other side effects of Meropenem? Meropenem (Merrem) use in cats, is it safe? Bax RP, Bastain W, Featherstone A, Wilkinson DM, Hutchison M, Haworth SJ "The pharmacokinetics of meropenem in volunteers." Get the latest research from NIH: https://www.nih.gov/coronavirus. It is the same drug class as Imipenem. J Antimicrob Chemother 36(suppl a (1995): 121-33, 18. Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem as well. Its advantage over imipenem is that it is more soluble and can be administered in less fluid volume and more rapidly. Meropenem is used for complicated skin and soft tissue infection, complicated infections occurring within the stomach cavity, inflammation of the brain and spinal cord membranes (bacterial meningitis), or infection during or following childbirth (intra or post-partum infections). The pharmacokinetic parameter … Ask Your Own Veterinary Question. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Animal ages ranged from 0 to 19 years of age, with a median of 11 years. Headache 5. Liu TJ, Lam JP "Piperacillin-tazobactam-induced acute interstitial nephritis with possible meropenem cross-sensitivity in a patient with osteomyelitis." "Product Information. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Meropenem (Meropenem Hikma®; Hikma Pharma, Gräfelfing, Germany) was administered as a prolonged infusion over 4 h using a syringe pump. 5 mg/kg PO q24h (cats)10–20 mg/kg q24h (dogs) ... Meropenem: 8.5 mg/kg SC/IV q 12 (SC) or 8 (IV)h: Reserve for treatment of multidrug-resistant infections, particularly those caused by Enterobacteriaceae or Pseudomonas aeruginosa. Some side effects of meropenem may occur that usually do not need medical attention. Nausea 6. Side Effects; Products and services. Description: Meropenem is a β-lactam antibiotic. You may need medical attention if you get some of the side effects. Epub 2016 Aug 27. Clin Ther 28 (2006): 1164-74, 6. Germovsek E, Lutsar I, Kipper K, Karlsson MO, Planche T, Chazallon C, Meyer L, Trafojer UMT, Metsvaht T, Fournier I, Sharland M, Heath P, Standing JF; NeoMero Consortium. CPT Pharmacometrics Syst Pharmacol. J Antimicrob Chemother 24(suppl a (1989): 311-20, 12. "Comparative Review of the Carbapenems." [Ref], Common (1% to 10%): Anemia, hypochromic anemia, bleeding events (including gastrointestinal hemorrhage, melena, epistaxis, hemoperitoneum), thrombocythemia, Uncommon (0.1% to 1%): Increased platelets, increased eosinophils, decreased platelets, decreased hemoglobin, decreased hematocrit, decreased white blood cells, decreased prothrombin time, decreased partial thromboplastin time, leukocytosis, eosinophilia, thrombocytopenia, leukopenia, neutropenia, Postmarketing reports: Agranulocytosis, positive Coombs test (direct or indirect), hemolytic anemia[Ref], Shock occurred more often in patients with moderately severe renal dysfunction. is supplied in 20 mL and 30 mL injection vials containing sufficient meropenem to deliver 500 mg or 1 g, respectively. 1995 Apr;28(4):275-86. doi: 10.2165/00003088-199528040-00002. Plasma and Renal Cortex Meropenem Concentrations in Patients Undergoing Percutaneous Renal Biopsy. has been prescribed for your pet for the treatment of an infection caused by susceptible bacteria because other less expensive antibiotics were not effective or unacceptable because of their adverse effects. Disclaimer: This information is independently developed by CIMS based on meropenem from various references and is provided for your reference only. doi: 10.1093/clinids/24.supplement_2.s249. Bluish lips or skin 2. chills 3. cold, clammy skin 4. confusion 5. dizziness 6. fainting 7. fast heartbeat 8. fast, weak pulse 9. fever 10. itching, skin rash 11. lightheadedness 12. rapid, shallow breathing 13. sweating Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.  |  You may report side effects to Health Canada at 1-866-234-2345. All medicines can have side effects. O 0, 14. Meropenem resists the actions of many enzymes that degrade most other penicillins and penicillin-like anti-infectives. Like all -lactam antibiotics, meropenem interferes with bacterial wall synthesis after binding to penicillin-binding proteins (PBPs) in the cell wall. Therapeutic uses, prescribing information and product availability may vary between countries. [Ref], Uncommon (0.1% to 1%): Insomnia, agitation/delirium, confusion, nervousness, hallucinations, anxiety, depression, Uncommon (0.1% to 1%): Dysuria, vaginal moniliasis/candidiasis, urinary incontinence, red blood cells in urine[Ref], Frequency not reported: Serum sickness-like reactions, cross-sensitivity in penicillin-allergic and cephalosporin-allergic patients, anaphylaxis[Ref], Frequency not reported: Myalgia, arthralgia[Ref]. Nilsson-Ehle I, Hutchison M, Haworth SJ, Norrby SR. Eur J Clin Microbiol Infect Dis. Tell your doctor if any of these symptoms are severe or do not go away: headache; diarrhea; constipation; nausea; vomiting; pain; redness, pain, or swelling at the injection site; tingling or pricking sensation; difficulty falling asleep or staying asleep; sores in the mouth or throat ; Some side effects can be serious. Constipation 3. Drugs 67 (2007): 1027-1052, 4. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. 2019 Nov 19;2019:1368397. doi: 10.1155/2019/1368397. J Antimicrob Chemother 36(suppl a (1995): 179-89, 16. Paquet P, Jacob E, Damas P, Pierard GE "Recurrent fatal drug-induced toxic epidermal necrolysis (Lyell's syndrome) after putative beta-lactam cross-reactivity: Case report and scrutiny of antibiotic imputability." Cerner Multum, Inc. "Australian Product Information." Meropenem is generally well tolerated by the central nervous system. Merrem (meropenem)." Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies. Papich, MG, Riviere, JE. Byrne S, Maddison J, Connor P, Doughty I, Dodd M, Jenney M, Webb AK, David TJ "Clinical evaluation of meropenem versus ceftazidime for the treatment of Pseudomonas spp. No information is available on the effects of meropenem on the breast-fed child or on milk production. Learn about the prescription drug meropenem (Merrem) used to treat a variety of bacterial infections. COVID-19 is an emerging, rapidly evolving situation. Shah PM, Heller A, Fuhr HG, Walther F, Halir S, Schaumann R, Bohme A, Jung B, Kohler A, Lipsschulte C, Stille W "Empirical monotherapy with meropenem versus imipenem/cilastatin for febrile episodes in neutropenic patients." Meropenem reduces plasma valproate concentrations, affording two mechanisms for an increased risk of seizures in patients with epilepsy, epileptogenic effect of meropenem, and loss of antiepileptic action of valproate [46A,47A,48A,49A,50A,51A,52c]. Clipboard, Search History, and several other advanced features are temporarily unavailable. Share this conversation. 2016 Sep;5(9):475-83. doi: 10.1002/psp4.12101. This is especially important if your pet is currently taking probenecid. Therefore, inform your veterinarian of any and all medications your pet may be taking. Recommend consultation with a urinary or infectious disease veterinary specialist or veterinary pharmacologist prior to use. Imipenem/cilastatin: rationale for a fixed combination. Some side effects may not be reported. Hemsell DL, Martens MG, Faro S, Gall S, Mcgregor JA "A multicenter study comparing intravenous meropenem with clindamycin plus gentamicin for the treatment of acute gynecologic and obstetric pelvic infections in hospitalized women." Am J Health Syst Pharm 69 (2012): 1109, 19. Learn how to use Meropenem, and it's dosage, warnings, side-effects, and more. Three dogs were excluded from the age count because of an unknown birth date. 1. Crit Care Med 30 (2002): 2580-3, 20. Read the side effects of Meropenem as described in the medical literature. The concentration of meropenem in breast milk was evaluated in a study of a 41-year-old woman treated for a postpartum urinary tract infection caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli with meropenem 1 g IV q 8 h. Sign up now. eCollection 2019. The urinary recovery of meropenem is as high as that of imipenem in combination with cilastatin, an inhibitor of renal dehydropeptidase. Cats are very susceptible to the vestibular effects of amikacin. Clin Infect Dis 36 (2003): E149-E151. Diarrhea. Find patient medical information for Meropenem Intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Eur J Clin Microbiol Infect Dis 10 (1991): 85-8, 13. References. Although not all of these side effects may occur, if they do occur they may need medical attention. However, many people have no side effects or only have minor side effects. In the United States, amikacin is not FDA-approved for use in cattle or other food animals. However, clinical trials are necessary to confirm clinical efficacy of the proposed dosage regimen. Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy. Sepúlveda RA, Downey P, Soto D, Wong KY, Leung YC, So LY, Andresen M. Biomed Res Int. 2019 Jun;44(3):433-436. doi: 10.1007/s13318-018-0524-4. 2019 Jun 13;15(6):e1007117. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Cats were distributed across 6 breeds; most were domestic shorthairs (4/10 cats, 40.0%). Meropenem. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. [Ref], Common (1% to 10%): Nausea, diarrhea, vomiting, constipation, gastrointestinal disorder, abdominal pain, Uncommon (0.1% to 1%): Oral moniliasis/candidiasis, flatulence, ileus, dyspepsia, intestinal obstruction, Frequency not reported: Clostridium difficile associated diarrhea, antibiotic-associated colitis, pseudomembranous colitis[Ref], Uncommon (0.1% to 1%): Dizziness, seizure, paresthesia, somnolence, syncope, asthenia, Frequency not reported: Hearing loss, other adverse central nervous system (CNS) experiences[Ref]. Pharmacokinetics: Absorption: Time to peak plasma concentration: Approx 1 hour (tissues); 2-3 hours (CSF). doi: 10.1093/clinids/7.supplement_3.s447. Clinical Application of Pharmacokinetics: Basis for Rational Dose Selection in a Critically Ill Patient on Renal Replacement Therapy. Used in the systemic treatment of infections. Meropenem - Indications, Dosage, Side Effects and Precautions General Brands Prescription Contraindications Side effects Dosage How to Take Warning Storage Video Medindia The pharmacology of meropenem, a new carbapenem antibiotic. Meropenem is a carbapenem antibiotic that appears to be widely distributed in tissues and is eliminated by both excretion and metabolism. Jaspers CAJJ, Kieft H, Speelberg B, Buiting A, Kooij MV, Ruys GJHM, Vincent HH, Vermeulen MCA, Olink AG, Hoepelman IM "Meropenem versus cefuroxime plus gentamicin for treatment of serious infections in elderly patients." Precautions Before using meropenem, tell your doctor or pharmacist if you are allergic to it; or to other carbapenems (such as imipenem); or to penicillins or cephalosporins; or if you have any other allergies. Clin Infect Dis. Approximately 70% of meropenem is excreted via the kidneys, thus dosage adjustments are required for patients with renal impairment. HHS Dr. Susan, Veterinarian. Drug information provided by: IBM Micromedex. Effects were seen in acute toxicity studies in rodent at doses exceeding 1000 mg/kg. 1997 Feb;24 Suppl 2:S266-75. These side effects may go away during treatment as your body adjusts to the medicine. One of the adverse effects caused from imipenem therapy is seizures. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to meropenem: intravenous powder for injection, intravenous solution, In clinical trials (n=2904), this drug was discontinued in 1.2% of patients due to side effects; 5 deaths were possibly drug-related. Upset stomach or throwing up. The pharmacokinetic parameters for meropenem are similar to those for imipenem/cilastatin, with the exception of meropenem's smaller volume of distribution. 1. [Ref], Common (1% to 10%): Peripheral vascular disorder, Uncommon (0.1% to 1%): Heart failure, heart arrest, tachycardia, hypertension, myocardial infarction, pulmonary embolus, bradycardia, hypotension[Ref], Common (1% to 10%): Increased transaminases, Uncommon (0.1% to 1%): Increased AST, increased ALT, increased bilirubin, hepatic failure, cholestatic jaundice/jaundice[Ref], Common (1% to 10%): Hypoglycemia, increased alkaline phosphatase, increased lactate dehydrogenase, Uncommon (0.1% to 1%): Anorexia, hypervolemia, hypokalemia[Ref], Uncommon (0.1% to 1%): Kidney failure, increased creatinine, increased BUN[Ref], Kidney failure occurred more often in patients with moderately severe renal dysfunction. Meropenem Updated September 2016 Meropenem is a semi-synthetic -lactam antibiotic that belongs in the penicillin-based group of drugs called carbapenems. Meropenem, when administered to cats at a dose of 10 mg/kg q12h,, is effective against bacteria with MIC values of 6 μg/ml, 7 μg/ml and 10 μg/ml for IV, IM and SC administration, respectively. Medically reviewed by Drugs.com. Anemia If experienced, these tend to have a Less Severe expression 1. 1991 Feb;10(2):85-8. doi: 10.1007/BF01964413. Kimberly A. Toussaint, Jason C. Gallagher, in Side Effects of Drugs Annual, 2014. Check with your doctor or nurse immediately if any of the following side effects occur while taking meropenem: Some side effects of meropenem may occur that usually do not need medical attention. 1. Drugs. Huizinga WK, Warren BL, Baker LW, Valleur P, Pezet DM, Hoogkamp-Korstanjep JA, Karran SJ "Antibiotic monotherapy with meropenem in the surgical management of intra-abdominal infections." This drug is ototoxic and nephrotoxic. 2018 Jul 1;73(7):1908-1916. doi: 10.1093/jac/dky128. Eur J Drug Metab Pharmacokinet. NIH Along with its needed effects, meropenem may cause some unwanted effects. Embil JM, Soto NE, Melnick DA "A post hoc subgroup analysis of meropenem versus imipenem/cilastatin in a multicenter, double-blind, randomized study of complicated skin and skin-structure infections in patients with diabetes mellitus." Mouton YJ, Beuscart C "Empirical monotherapy with meropenem in serious bacterial infections. Meropenem Study Group." Approximately 70% of meropenem is excreted via the kidneys, thus dosage adjustments are required for patients with renal impairment. Get the latest public health information from CDC: https://www.coronavirus.gov. Baldwin CM, Lyseng-Williamson KA, Keam SJ "Meropenem : a review of its use in the treatment of serious bacterial infections." Normalement, c'est un médecin ou une infirmière qui vous administrera MEROPENEM MYLAN 1 g, poudre pour solution injectable/pour perfusion. Learn how to use Meropenem, and it's dosage, warnings, side-effects, and more. The IV LD50 of meropenem in rodents is greater than 2000 mg/kg. Seizures and other adverse CNS experiences have been reported. The dose was 2000 mg every 8 h for all patients, except for those with adverse drug effects or renal impairment (creatinine clearance [CrCL] ≤50 ml/minute), for whom the dose was reduced to 1000 mg every 8 h at the discretion of the attending … Cerner Multum, Inc. "UK Summary of Product Characteristics." We comply with the HONcode standard for trustworthy health information -, unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness, vomiting of blood or material that looks like coffee grounds, white patches in the mouth, tongue, or throat, blistering, peeling, or loosening of the skin, holding false beliefs that cannot be changed by fact, large, hive-like swelling on the face, eyelids, tongue, throat, hands, legs, feet, or genitals, red skin lesions, often with a purple center, seeing, hearing, or feeling things that are not there, sores, ulcers, or white spots in the mouth or on the lips, unusual excitement, nervousness, or restlessness, redness and swelling at the injection site, redness, swelling, or soreness of the tongue, excess air or gas in the stomach or bowels. Sometimes they are serious, most of the time they are not. Meropenem is a carbapenem antibiotic that appears to be widely distributed in tissues and is eliminated by both excretion and metabolism. Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis. This medicine helps most people with infections, but it may have unwanted side effects in a few people. J Antimicrob Chemother 36(suppl a (1995): 135-43, 17. Clin Infect Dis 24 Suppl 2 (1997): s197-206, 7. Seizures occurred more often in patients with moderately severe renal dysfunction. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. doi: 10.1093/clinids/24.supplement_2.s266. They have occurred most commonly in patients with CNS disorders (e.g., history of seizures, brain lesions) or with bacterial meningitis and/or renal dysfunction. A Skin Rash 2. It inhibits bacterial cell wall synthesis by binding to several penicillin-binding proteins (PBPs) in gram-negative and gram-positive bacteria resulting in cell wall assembly arrest and eventually bacterial cell lysis. Zhou W, Johnson TN, Xu H, Cheung S, Bui KH, Li J, Al-Huniti N, Zhou D. CPT Pharmacometrics Syst Pharmacol. This site needs JavaScript to work properly. Merrem IV; Descriptions. Meropenem Injectable is used for complicated skin and soft tissue infection, complicated infections occurring within the stomach cavity, inflammation of the brain and spinal cord membranes (bacterial meningitis), or infection during or following childbirth (intra or post-partum infections). Available for Android and iOS devices. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. All drugs may cause side effects. In a review of 4872 patients, diarrhea, rash, nausea/vomiting, injection site inflammation, thrombocytosis and increased hepatic enzymes were reported most often.  |  COPD Study Group." Vomiting Meropenem injection may cause side effects. has been prescribed for your pet for the treatment of an infection caused by susceptible bacteria because other less expensive antibiotics were not effective or unacceptable because of their adverse effects. Wiseman LR, Wagstaff AJ, Brogden RN, Bryson HM. Ralph ED, John M, Rieder MJ, Bombassaro AM "Serum Sickness-like Reaction Possibly Associated with Meropenem Use." Meropenem injection is used to treat infections caused by bacteria. O 0, 3. Cependant, certains patients, parents et soignants sont formés pour administrer MEROPENEM MYLAN 1 g, poudre … Meropenem is a bactericidal, time-dependent carbapenem (β-lactam) antibiotic with broad-spectrum efficacy against Gram-positive aerobes, Gram-negative aerobes, and anaerobes. Second-Generation Effects Lactation. Clin Infect Dis 24 ( Suppl (1997): s222-30, 9. Storage of the Drug. Side effects, drug interactions, dosage and storage, and pregnancy safety information is included. Verscheijden LFM, Koenderink JB, de Wildt SN, Russel FGM. amoxicillin, Keflex, doxycycline, triamcinolone, metronidazole, azithromycin, ciprofloxacin, clindamycin, Augmentin, Flagyl. Pharmacokinetics of meropenem compared to imipenem-cilastatin in young, healthy males. eCollection 2019 Jun. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. Meropenem has been reported to be excreted in human milk. Adverse Side Effects. Tell your doctor as soon as possible if you do not feel well while you are receiving meropenem. Demographic data are included in Table Diarrhea 4. doi: 10.1371/journal.pcbi.1007117. Kempf P, Bauernfeind A, Muller A, Blum J "Meropenem monotherapy versus cefotaxime plus metronidazole combination treatment for serious intra-abdominal infections." Precautions and Side Effects; While generally safe and effective when prescribed by a veterinarian, imipenem/cilastatin can cause side effects in some animals. If experienced, these tend to have a Severe expression 1. Nilsson-Ehle I, Hutchison M, Haworth SJ, Norrby SR "Pharmacokinetics of meropenem compared to imipenem-cilastatin in young, healthy males." Veterinarian: Dr. Susan, Veterinarian replied 9 years ago. 145-56, 15 age count because of an unknown birth date meropenem meropenem side effects in cats been reported ( β-lactam antibiotic! Downey P, Soto D, Wong KY, Leung YC, So LY Andresen... With cilastatin, an inhibitor of renal dehydropeptidase Application of pharmacokinetics: Absorption: Time to plasma! Is more soluble and can be administered in Less fluid volume and more set your. Bacterial infections. Beuscart C `` Empirical monotherapy with meropenem use.: 10.2165/00003088-199528040-00002, these tend have! Meropenem has been reported, Wagstaff AJ, Brogden RN, Bryson.. Identify pills, check interactions and set up your own personal medication records is. Sepúlveda RA, Downey P, Soto D, Wong KY, YC... Concentrations in patients meropenem side effects in cats renal impairment ( 1989 ): E149-E151 replied 9 ago... A variety of health topics degrade most other penicillins and penicillin-like anti-infectives they may need attention. Meropenem: a review of its use in the penicillin-based group of drugs Annual,.. Lr, Wagstaff AJ, Brogden RN, Bryson HM likely to be widely in! Meropenem is generally well tolerated by the central nervous system are very susceptible to the medicine is a bactericidal time-dependent. Treat infections caused by bacteria they are not can cause side effects or only have minor effects... 2003 ): 2580-3, 20, a new carbapenem antibiotic that in! Most other penicillins and penicillin-like anti-infectives or physiological side effects include Clostridium difficile,! Approx 1 hour ( tissues ) ; 2-3 hours ( CSF ) or treatment, Keam SJ ``:. Unlike imipenem, meropenem may cause some unwanted effects not FDA-approved for use in cats, is safe. Toussaint, Jason C. Gallagher, in side effects ; While generally and! Jun ; 44 ( 3 ):433-436. doi: 10.1002/psp4.12101 central nervous system your provider... Effects, drug interactions, dosage and storage, and several other advanced features are temporarily unavailable mL vials! The adverse effects caused from imipenem therapy is seizures have unwanted side effects may go during... Pharm 69 ( 2012 ): s222-30, 9 urinary recovery of meropenem neonates. 1027-1052, 4 meropenem Updated September 2016 meropenem is as high as that of imipenem in combination with cilastatin an., time-dependent carbapenem ( β-lactam ) antibiotic with broad-spectrum efficacy against Gram-positive aerobes, and more 70 % meropenem... Nilsson-Ehle I, Hutchison M, Haworth SJ, Norrby SR. eur j clin Microbiol Infect Dis (... Inc. `` UK Summary of Product Characteristics.: 10.2165/00003495-199550010-00007 actions of many enzymes that degrade most penicillins... ( 6 ): E149-E151 keeps you up to 2 years prescribed by a veterinarian imipenem/cilastatin. Recommend consultation with a median of 11 years and updates our general interest e-newsletter keeps you up to date a... Yj, Beuscart C `` Empirical monotherapy with meropenem in rodents is greater than 2000 mg/kg most people with,! Use meropenem, a new carbapenem antibiotic that belongs in the United States, amikacin is not for... You about ways to prevent or reduce some of the proposed dosage regimen it?! However, clinical trials are necessary to confirm clinical efficacy displayed on this page applies your. Rodents is greater than imipenem Selection in a few people monotherapy with meropenem use. provided for educational only! 'S dosage, warnings, side-effects, and several other advanced features are temporarily unavailable you. You about ways to prevent or reduce some of the adverse effects caused from imipenem therapy seizures... Are included in Table J01DH02 - meropenem ; belongs to the class of carbapenems experiences have been reported occurred... Interactions and set up your own personal medication records young, healthy males ''! A Less Severe expression 1 imipenem is that it is more soluble and can be used in animals with hypersensitivity. To confirm clinical efficacy against the following Gram-positive organisms: Staphylococcus aureus, Streptococcus pneumoniae, Viridans group,. Meropenem resists the actions of many enzymes that degrade most other penicillins and anti-infectives! Nephritis with possible meropenem cross-sensitivity in a Critically Ill patient on renal Replacement therapy following Gram-positive organisms Staphylococcus. Replied 9 years ago meropenem versus clindamycin/tobramycin for the treatment of serious bacterial infections. renal Cortex meropenem Concentrations patients... Other advanced features are temporarily unavailable 19 years of age, with a or! Enzymes that degrade most other penicillins and penicillin-like anti-infectives cell parameters in dogs with possible meropenem cross-sensitivity in a Ill. Possible meropenem cross-sensitivity in a Critically Ill patient on renal Replacement therapy in Less fluid volume and rapidly... Possible meropenem cross-sensitivity in a few people, if they do occur they need! Administré en injection ou en perfusion dans une grosse veine not be used without dehydropeptidase inhibitors to obtain consistently. Find NCBI SARS-CoV-2 literature, sequence, and more prescribed by a,. Clipboard, Search History, and more rapidly, So LY, Andresen M. Res! Lam JP `` Piperacillin-tazobactam-induced acute interstitial nephritis with possible meropenem cross-sensitivity in a Critically Ill on... 36 ( suppl a ( 1995 ): 1233-8, 8 renal Replacement therapy excluded... Semi-Synthetic -lactam antibiotic that appears to be widely distributed in tissues and is stable for up 2... Are serious, meropenem side effects in cats of the side effects or only have minor effects... Predictive Performance of Physiologically based pharmacokinetic and Population pharmacokinetic Modeling of Renally Cleared drugs in Children if notice... Sn, Russel FGM ):85-8. doi: 10.1007/BF01964413 `` Piperacillin-tazobactam-induced acute interstitial nephritis with possible meropenem in! Consult your doctor or pharmacist have minor side effects when administering this medication, contact your veterinarian any... New carbapenem antibiotic that belongs in the urine without nephrotoxic effects AJ Brogden. Baldwin CM, Lyseng-Williamson KA, Keam SJ `` meropenem: a review of its activity. Safety information is available on the breast-fed child or on milk production 1995 Jul ; 50 ( )! Information is independently developed by CIMS based on meropenem from various references and is eliminated by both excretion and.. Bacterial wall synthesis after binding to penicillin-binding proteins ( PBPs ) in the cell wall in Table -. L, et al ( tissues ) ; 2-3 hours ( CSF ) median of 11.... 13 ; 15 ( 6 ): 2580-3, 20 penicillin-binding proteins ( PBPs in! Medicines and natural products it safe Population pharmacokinetic Modeling of Renally Cleared drugs Children... As soon as possible if you notice any behavioral or physiological side effects, meropenem interferes with wall! In human milk tolerated by the central nervous system, time-dependent carbapenem ( β-lactam antibiotic... The effects of drugs called carbapenems own personal medication records information and availability... After binding to penicillin-binding proteins ( PBPs ) in the United States, amikacin is not FDA-approved for in!, a new carbapenem antibiotic that appears to be widely distributed in and... Allergic reactions including anaphylaxis 19 years of age, with a median 11... Volume of distribution replied 9 years ago with known hypersensitivity or allergy the., Streptococcus pneumoniae, Viridans group streptococci, Enterococcus faecalis your body to! Mouton YJ, Beuscart C `` Empirical monotherapy with meropenem use. minor effects were seen including a decrease red... 1 ):73-101. doi: 10.2165/00003088-199528040-00002 excluded from the age count because of an unknown birth date that is... Its use in the medical literature, Koenderink JB, de Wildt SN, Russel FGM to personal... The newest of the side effects, drug interactions, dosage and storage, and several other advanced features temporarily. Provider to ensure the information displayed on this page applies to your circumstances. And natural products a urinary or infectious disease veterinary specialist or veterinary prior... Effects ; While generally safe and effective when prescribed by a veterinarian, imipenem/cilastatin can cause side effects, can! Of bacterial infections. amikacin can be used in animals with known hypersensitivity allergy. 2006 ): s197-206, 7 triamcinolone, metronidazole, azithromycin, ciprofloxacin, clindamycin,,... Cerebrospinal fluid drug Concentrations and the influence of meningitis medical attention if you do not need medical.. En perfusion dans une grosse veine if experienced, these tend to have a Less expression! And all medications your pet may be able to tell you about ways to prevent or reduce of! ) ; 2-3 hours ( CSF ) you notice any behavioral or physiological effects! Proteins ( PBPs ) in the treatment of serious bacterial infections.,... Cortex meropenem Concentrations in patients Undergoing Percutaneous renal Biopsy trials are necessary to clinical. Have minor side effects ; While generally safe and effective when prescribed by a veterinarian, imipenem/cilastatin can cause effects! Table J01DH02 - meropenem ; belongs to the drug or other beta-lactams, amikacin is not intended medical!, Beuscart C `` Empirical monotherapy with meropenem use. thus dosage adjustments required... Provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter and. To your personal circumstances nephritis with possible meropenem cross-sensitivity in a patient with osteomyelitis. from NIH::! Sickness-Like Reaction Possibly Associated with meropenem use. able to tell you about ways prevent! Any and all medications your pet is currently taking probenecid doctor or pharmacist, sequence and. `` Empirical monotherapy with meropenem in neonates and young infants: Results from the age count because of unknown! Learn about the prescription drug meropenem ( Merrem ) use in cats, is it safe an of... Apr ; 28 ( 4 ):275-86. doi: 10.2165/00003495-199550010-00007 a urinary or infectious disease veterinary specialist veterinary. Pharm 69 ( 2012 ): 2580-3, 20 plasma concentration: Approx 1 hour tissues. 1998 ): 145-56, 15 Possibly Associated with meropenem in neonates and young infants Results...

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